Molecular Oxygen for Chemistry, Research and Laboratory

O2Kem is an independent company created on 2012 and focused on the use of molecular oxygen for chemistry, research and laboratory purposes.

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About Us

Since 2012, O2Kem supplies Pharmaceutical and Biotechnology companies with a wide range of value added services.

O2Kem uses molecular oxygen for different applications and supports these applications with associated chemistry and analytical services.

organizational-chart-oxygen-chemistry-research-laboratory

Our Services

O2Kem supplies a wide range of value added services around its major molecular oxygen chemistry know-how. Synthesis of different Reactive Oxygen Species (ROS) allows access to unknown by-products generated by oxidative stress as well as research on new active derivatives

Antioxidant assessment (in vitro)

DPPH assay
Superoxide anion scavenging activity
Peroxynitrite scavenging activity
Trolox equivalent antioxidant capacity assay (TEAC)
Reducing Power (RP)
Inhibition of Lipid Peroxidation: β-carotene-linoleic acid assay

Contract

Fee for services or typical research contracts are proposed
IP, confidentiality and proprietary information are strictly observed

Custom synthesis as support of research

Synthesis on milligram to multi-gram scale, simple or more complex (typically 10-15 steps)
Preparation of cold-labeled reference compounds (²H, ¹³C) to support studies
Chemistry performed using Schlenk techniques under a dry argon atmosphere

For examples: see the catalog products section

R&D activities

Since 2012, O2Kem has been developing its own research work which has enabled to be accredited for French Research Tax Credit (“Crédit d’Impôt Recherche”; CIR) status every three years.
O2Kem licenses access to SciFinderⁿ, a CAS product, to carry out its bibliographic research and technological watch.

CAS, a division of the American Chemical Society, owns all rights and interests in SciFinderⁿ and is neither affiliated with nor specifically endorsing O2Kem.

ROS Chemistry :

Synthesis of Reactive Oxygen Species (ROS) from molecular oxygen: ¹O₂, O₃. Further access to other derivatives of ROS: O₂•-, OH•, NO•, ONOO-

Biological processes

Molecular damage simulation: lipids damages

Analytical

O2Kem is able to offer a large variety of analyses thanks to close collaboration with different academic and private laboratories

Classical structural analysis characterization for new chemical entity includes:
¹H NMR and if necessary heteronuclear (¹³C, ³¹P, ¹⁹F…) NMR, 2D NMR (COSY, HSQC, HMBC)
IR
Mass spectrometry
HPLC/GC
Melting point
Elemental analysis